Informatics Publishing Limited

Rohan R. Vakhariya ¹, Swati Talokar ¹, Archana R. Dhole ¹, S. K. Mohite ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. 415404, IN

Abstract

Majority of Ayurvedic practitioners uses traditional herbal preparations for their treatment purposes made by them. So it is necessary to improve safety of herbal drugs by developing certain quality control parameters and by following the WHO guidelines for herbal medicines. Our adulteration. Now days, old methods are necessary but there are lots of limitations to these methods due to shortage of many drugs, unavailability or limited source, adulteration, lack of knowledge of drug identification and adverse effects of drugs etc. Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. The World Health Organization (WHO) in 1999 has given a detail protocol for the standardization of herbal drugs comprising of a single content, but very little literature is available for the standardization of Shatavari Churna. Two marketed preparations were used for the study. Performed the various parameters including organoleptic characteristics and physicochemical parameters. The set parameters were found to be sufficient to standardize the Shatavari Churna.

Keywords

Traditional, Standardization, Shatavari Churna, Physicochemical Parameters.

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Rohan R. Vakhariya ¹, Swati Talolkar ¹, Archana R. Dhole ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist. Sangli-415,404 Maharashtra, IN

Abstract

OPLC is coming of age. Its rudimentary beginnings, some 25 years ago, have lead to innovative, highperformance products. The commercialization of modern, high efficiency columns has eliminated the need for analysts to prepare their own from TLC plates, making the technique even more accessible. Optimum performance laminar chromatography (OPLC) is a pumped flow chromatography technique that combines the user-friendly interface of HPLC with the capacity of flash chromatography and the multidimensionality of thinlayer chromatography. This review will describe the basis of modern OPLC instrumentation and the separation techniques, as well as give a brief account of some recent applications in OPLC.

Keywords

OPLC, Instrumentation, Application.

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Swati S. Talokar ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Tal Walwa, Dist Sangli, Maharashtra, IN

Abstract

Technology transfer is a critical and integral part of drug development process. This path for is dependent on completion of technology transfer to the product site at an affordable cost. The purpose of this review article is to discuss various aspects of technology transfer. This article highlights the goals, importance, facets and various models associated with technology transfer. This article also discuss some of examples of technology transfer in India as well as in global market.

Keywords

Technology Transfer, Facets, Model.

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Rohan R. Vakhariya ¹, Swati S. Talokar ¹, V. R. Salunkhe ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN

Abstract

The present research work support preformulation, formulation, development and optimization of solid lipid nanoparticles containing simvastatin as an antihyperlipidemic drug. The different batches of formulation were obtained using simvastatin as active pharmaceutical ingredient, stearic acid as the source of lipid and β - cyclodextrin as a polymer. Solid lipid nanoparticles of simvastatin were prepared by precipitation method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result was found to be within standard limit. FTIR study reports indicated that there was no interaction between Simvastatin and other excipients. Motic microscope shown that the nanoparticles size ranges from 100-550nm. Percent entrapment efficiency was between 61.40% - 92.30%. Based on the resultants of the entrapment and particle size of nanoparticles, formulation S6 was observed to be optimized formulation. The optimized formulation exhibited 63.75% cumulative drug release after 24 h. The optimized batch shows mean of zeta potential at -44.0 mV.

Keywords

Antihyperlipidemic Drug, β–Cyclodextrin, Entrapment Efficiency, Zeta Potential, Motic Microscope.

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Swati S. Talokar ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Dist–Sangli Tal–Walwa Maharashtra, IN

Abstract

Microspheres are powders consisting of proteins or synthetic polymers. Microsphere is one approach of delivering active drug ingredient to targeted site. They can overcome the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Microspheres received much attention for prolonged release as well as for targeting anticancer drugs to the tumor. The present study describes formulation of Lomefloxacin microspheres. In future by combining various other strategies, microspheres will find the central place in novel drug delivery. Formulated microsphere is evaluated for its surface morphology, particle size, in vitro drug release, drug entrapment efficiency. All the results were up to the mark and were found satisfactory.

Keywords

Targeted Site, Carrier, Novel Drug, Entrapment Efficiency.

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Swati Talokar ¹, Rohan R. Vakhariya ¹, A. R. Dhole ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN

Abstract

Emerge in the use of herbal product has given rise to various forms of abuse and adulteration. Therefore to asses quality of drugs standardization of herbal formulations is essential. The need of quality control for ayurvedic drug is due to the commercialization of ayurvedic pharmacy as use of ancient method for preparation has been reduced. The absence of post-market surveillance and the paucity of test laboratory facilities also make the quality control of aurvedic medicines exceedingly difficult. A very little literature is available on standardization of Gulvel churna, an attempt has been made to standardize it. In the present study two marketed product of Gulvel were standardized using different parameters including organoleptic characteristics and physicochemical. The set parameters were found to be sufficient to standardize the Gulvel churna.

Keywords

Standardization, Gulvel churna, Organoleptic Characterization.

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Rohan R. Vakhariya ¹, Rutuja R. Shaha ¹, Archana R. Dhole ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa, Dist Sangli, Maharashtra, IN

Abstract

There is an ever-present need for non-allergenic antibacterial and antifungal wound dressing with a superior healing property for chronic ulcers. Among the entire modern wound healing dressings, hydrogel has a good capacity to donate moisture or absorb exudate and thereby providing a moist environment to facilitate wound healing process and at the same time protect the wound too. In the present study, povidne iodine loaded acrylamide based biocompatible biodegradable hydrogel dressings incorporating alginate, chitosan and gelatin showed good fluid absorbance capacity. The addition of honey showed improved tensile strength and moisture absorbance capacity of the hydrogel sponge. Addition of turmeric and aloe vera give additional wound healing properties. Chitosan and Alginate films with different Aloe vera contents (5, 15, 25 and 35%) and turmeric contents (5, 15, 25 and 35%) were prepared and its properties evaluated in terms of thickness, transparency, swelling behavior and in vitro degradation.

Keywords

Chitosan, Hydrogel, Aloe vera, Turmeric.

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Rohan R. Vakhariya ¹, Swati S. Talokar ¹, V. R. Salunkhe ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN

Abstract

People with mild cognitive impairment have problems with memory, language, thinking or judgment that are greater than the cognitive changes associated with normal aging. Cognitive disorders can be objectively measured in cognitive tests, but the changes in cognitive abilities are usually not serious enough to interfere with daily life and independence. A person with cognitive impairment has an increased risk of developing Delirium, Dementia Alzheimer's disease and Amnesia, but some people with cognitive impairment remain stable and others show improved cognitive abilities over time. There is no proper cure for the cognitive disorders and much of the treatments available have been able to only delay the progression of the disorders or provide symptomatic relief for a short time period. Therefore there is need for a different approach to the treatment of these cognitive disorders. Different medicinal plants have been used since ancient times in the treatment of various cognitive disorders. Therefore pharmacological screening of medicinal plants may provide useful leads in the discovery of new drugs for the treatment of cognitive disorders. Variety of medicinal plants which can be used in cognitive enhancement is reviewed in this article. Phytochemical substances such as alkaloids, curcuminoids, triterpenoids and withenolides with pharmacological activities related to cognitive disorders treatment are discussed in this review.

Keywords

Cognitive Disorders, Alzheimer’s Disease, Medicinal Plants, Cognitive Enhancement, Phytochemical Substances.

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Rutuja R. Shah ¹, Abhijeet Jadhav ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN

Abstract

The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

Keywords

Solubility, Bicalutamide, Prostate Cancer, Microspheres, Tablets.

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Rutuja R. Shah ¹, Rutuja S. Shah ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN

Abstract

Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner.

Keywords

Floating Microspheres, Glimepiride, in-vitro Drug Release, Solubility.

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